Dear Toxic Hairball,
I would like to nominate a disease, not a person; the Black Plague.
I have been studying history for clues as to why we are like we are, and in the 14th century there was no germ theory to help us understand. So in Europe one of three, by some accounts half the population succumbed, horrible deaths, and it seemed like the Wrath of God...the End of the World.
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Did that horrible disease impact our collective psyche into the present era? Would there be less shame, guilt, blame in our culture if our ancestors had not endured the Black Death?