I don't know about most Americans as I can only answer for myself , I don't have a problem with Persians or Iranians.
I, myself have no problem with any people. Regardless of who they are.
How do Persian and Iranian people think about Americans?
Your question is odd...
I can't speak for all Americans, but for me they are just like any other group of people. Some are good, some are bad. Most are just trying to live their lives the best they know how.
I think of all people as individuals. Good and kind people come from many backgrounds, as do cruel and evil people.