What could be the funniest opening lines for a public speech? Any suggestions for a comedy speaker.

I think it really depends on the audience and the subject matter, but I'd suggest starting with something unexpected.

Also don't be afraid to make fun of yourself a bit.

I gave a short talk about Blurtit at a local tech conference recently, and I started with the line "what's cooking?" accompanied by a picture of Hulk Hogan eating spaghetti.

I don't think many people understood why I went with a wrestling theme for my slides, but it got a few laughs anyway.

In-jokes are always good; something that your audience can all relate to.

Alternatively, tapping in on a current event that everyone has found funny could be good too.

Agreed Kass! In-jokes are one of the medium if the audiences are known to us. But if one has to speak in front of unknown, the idea about making fun of the speaker himself, would work more.

I remember one line that compelled me to laugh and that is “If it wasn’t for all of you here today, I would be alone”.  Lines like these always create a lighter atmosphere in the event. We can also invite speakers who are best in the particular form of speaking like after dinner speakers, good comedians and celebrities. I am having a video of a successful event which can give you the insight about it

Highlights from The JLA Real Variety Show 2013 from JLA on Vimeo.